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    Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage ☶ research sciencedirect.com
    via Ugur 1 month ago |
    Archive.org Archive.today Ghostarchive

Highlights

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Cldn5 mosaic loss causes size-selective BBB permeability to tracers up to 10 kDa in size
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Adult-induced Cldn5 loss causes seizures and is lethal
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scRNA-seq excludes cell-autonomous transcriptional changes in endothelial cells
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Leakage causes endothelial and glial inflammation

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