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    So, eating habits can change? and they are linked to our genes? WOW.

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      Receiving “No route matches [GET]” when clicking on one of the tags.

      Figured out it’s because clicking the tags on the header adds one unnecessary “t/” in the URL? Is anyone else experiencing this?

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        Yes, indeed. Fixed.

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          Definietely improves the quality of the research as you have to present everything. However, protocols can change on-the-go and that may cause a problem.

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            Great idea! ‘News’ tag has been created.

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              Some questions:

              1. How is the kleisin–HAWK DNA-bound subcomplex and the hinge region is CTCF motif specific?
              2. Which force makes the kleisin–HAWK DNA-bound subcomplex go a direction by which the extrusion happens?
              3. Why cohesin SMC complexes have no such mechanism?
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                For the 1st question:

                It was shown before that C-terminus of CTCF protein interacts with cohesin complexes (probably with condensin too). So, TAD-inward motifs leads to a CTCF-cohesin interaction, if CTCF is bound, of course.

                For the 2nd question:

                In this paper, they proposed that a unidirectional movement can be achieved if two heads (subcomplexes) have different DNA-binding affinities. The weaker one will move forward upon separation, and the other will follow. However, I couldn’t find any explanation for a possible reverse movement, i.e. in the case of loop dissociation.

                For the 3rd, I don’t have an answer too :)

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                Do you believe people will post anonymous papers here? I don’t think so. There’s already a way to mark yourself as the paper author, it should be enough for all cases. Besides, forcing people to use whatever naming convention is problematic, as people may have many (plausible) reasons to use a social name rather than a “real” name.

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                  No, I am not talking about the anonymous posts. I am talking about the other side, if you will. Will people want to post their papers and comment to others with their names or social names? I don’t believe forcing anyone ti anything so that’s why I open this. I just wanted to hear your thoughts :)

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                  Really nice solution to an long-lasting problem.

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                    Added. Since the website has just released, I don’t see any reason not to add these tags.

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                      Thanks!