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Elegant work establishing meal associated thermogenesis leading to satiation; Gut-Secretin-Brown Fat Thermogenesis-Brain (Satiation).

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    This is really a good study to show Gut-BAT-Brain axis. Unfortunately, they couldn’t succeed weight loss in obes mice by secretin infusion, but they indicated BAT as an alternative target.

    What about CL (CL-316,243) in Figure 3G, or GLP1 analog in Figure S6? They seem highly promising for weight loss. Are they used in clinics?