Paperkast is a link-aggregator website for academic article discussion.
Please visit our about page for more information!
  1. 3
  1.  

  2. 2

    An epigenetic focused small molecule inhibitor screen identifies CBP/EP300 bromodomain inhibitors as enhancers of human somatic cell reprogramming. Inhibition of acetyltransferase activitiy of these two proteins decreases reprogramming efficiency, indicating different roles for different domains during reprogramming. CBP/EP300 bromodomains are found to maintain the cell-type specific gene expression e.g. PRRX1 (a master mesenchymal transcription factor), thus, bromodomain inhibitors facilitate reprogramming.