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    An epigenetic focused small molecule inhibitor screen identifies CBP/EP300 bromodomain inhibitors as enhancers of human somatic cell reprogramming. Inhibition of acetyltransferase activitiy of these two proteins decreases reprogramming efficiency, indicating different roles for different domains during reprogramming. CBP/EP300 bromodomains are found to maintain the cell-type specific gene expression e.g. PRRX1 (a master mesenchymal transcription factor), thus, bromodomain inhibitors facilitate reprogramming.