Highlights • Cldn5 mosaic loss causes size-selective BBB permeability to tracers up to 10 kDa in size • Adult-induced Cldn5 loss causes seizures and is lethal • scRNA-seq excludes cell-autonomous transcriptional changes in endothelial cells • Leakage causes endothelial and glial inflammation
On the genetic basis of tail-loss evolution in humans and apes
posted by KenanSevin28786 - 1 month ago
Protein design: the experts speak - Nature Biotechnology
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Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage
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Regulatory activity is the default DNA state in eukaryotes
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Transcription factor exchange enables prolonged transcriptional bursts
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